How does sertraline make you feel?

Sertraline is a medication that is commonly prescribed for the treatment of depression, anxiety disorders, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). If you have been prescribed sertraline, you may be wondering how it will make you feel. Here are some potential effects of sertraline and what you can expect when taking this medication:

Improvements in mood

One of the primary effects of sertraline is an improvement in mood. Sertraline works by increasing the levels of serotonin, a neurotransmitter in the brain that regulates mood, in the brain. By increasing serotonin levels, sertraline can help to alleviate feelings of sadness, hopelessness, and other symptoms of depression.

Reductions in anxiety

In addition to improving mood, sertraline can also help to reduce anxiety. Sertraline is often prescribed for the treatment of anxiety disorders, such as generalized anxiety disorder (GAD), social anxiety disorder, and panic disorder. By increasing serotonin levels, sertraline can help to reduce feelings of worry, fear, and anxiety.

Side effects

While sertraline can be very helpful for treating a variety of conditions, it can also cause side effects. Common side effects of sertraline can include nausea, diarrhea, headaches, and difficulty sleeping. These side effects are usually mild and go away on their own after a few days or weeks. However, if you experience any severe or persistent side effects, it is important to contact your doctor right away.

Sexual dysfunction

Another potential side effect of sertraline is sexual dysfunction. Sertraline can cause a decrease in libido, difficulty achieving orgasm, and other sexual problems. If you experience sexual dysfunction while taking sertraline, it is important to talk to your doctor. They may be able to adjust your dosage or switch you to a different medication to help alleviate your symptoms.

Energy levels

Some individuals may experience changes in their energy levels while taking sertraline. For some individuals, sertraline can cause feelings of tiredness or lethargy. For others, it can cause feelings of restlessness or agitation. If you experience changes in your energy levels while taking sertraline, it is important to talk to your doctor.

Appetite changes

Sertraline can also cause changes in appetite. Some individuals may experience an increase in appetite, while others may experience a decrease in appetite. If you experience changes in your appetite while taking sertraline, it is important to talk to your doctor. They may be able to provide guidance on how to manage these changes.

In conclusion, sertraline can have a variety of effects on the body and mind. It can improve mood, reduce anxiety, and alleviate other symptoms of depression and anxiety disorders. However, it can also cause side effects, including nausea, sexual dysfunction, and changes in energy levels and appetite. If you are considering taking sertraline, it is important to work closely with your doctor to determine the best treatment plan for your unique needs.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:

    France

    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr

    Spain

    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es

    Germany

    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de

    Italy

    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist

    France

    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca

    Spain

    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717

    Germany

    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222

    Italy

    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284

    Netherlands

    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113

    Portugal

    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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