What to avoid when taking sertraline?

Sertraline is a medication that is commonly prescribed for the treatment of depression, anxiety disorders, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). If you have been prescribed sertraline, it is important to know what to avoid while taking this medication to ensure its effectiveness and avoid potential side effects. Here are some things to keep in mind:

Alcohol

One of the most important things to avoid while taking sertraline is alcohol. Alcohol can interact with sertraline and increase the risk of side effects such as dizziness, drowsiness, and difficulty concentrating. In addition, alcohol can worsen symptoms of depression and anxiety, making it less effective to take sertraline.

Grapefruit and grapefruit juice

Grapefruit and grapefruit juice contain compounds that can interact with sertraline and increase the risk of side effects. This is because grapefruit can affect the way your body processes medications, including sertraline. To avoid these interactions, it is best to avoid grapefruit and grapefruit juice while taking sertraline.

Other medications

It is important to talk to your doctor before taking any other medications while on sertraline. Certain medications, including other antidepressants, can interact with sertraline and increase the risk of side effects. This also includes over-the-counter medications and herbal supplements.

St. John’s Wort

St. John’s Wort is an herbal supplement that is sometimes used to treat depression. However, it can interact with sertraline and increase the risk of side effects. It is important to talk to your doctor before taking St. John’s Wort or any other herbal supplements while on sertraline.

Caffeine

While caffeine is generally safe to consume in moderation, it is important to be mindful of your caffeine intake while taking sertraline. Caffeine can interact with sertraline and increase the risk of side effects such as anxiety, restlessness, and difficulty sleeping. If you notice that caffeine is affecting your symptoms while on sertraline, it may be best to reduce your caffeine intake.

Driving and operating machinery

Sertraline can cause drowsiness, dizziness, and other side effects that can make it difficult to drive or operate machinery. If you experience these side effects while taking sertraline, it is important to avoid driving or operating machinery until you know how the medication affects you.

In conclusion, there are several things to avoid while taking sertraline to ensure its effectiveness and avoid potential side effects. It is important to avoid alcohol, grapefruit and grapefruit juice, other medications, St. John’s Wort, and excessive caffeine. It is also important to be mindful of driving and operating machinery while on sertraline. If you have any questions or concerns about taking sertraline, it is important to talk to your doctor. By following these tips, you can help to ensure the safe and effective use of sertraline for the treatment of depression, anxiety disorders, OCD, PTSD, and PMDD.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: