What are the scary side effects of sertraline?

While sertraline is generally considered safe and effective for the treatment of depression, anxiety disorders, OCD, PTSD, and PMDD, it can cause side effects in some individuals. Most side effects of sertraline are mild and go away on their own after a few days or weeks. However, there are some rare but potentially serious side effects that can occur. Here are some of the scary side effects of sertraline:

Suicidal thoughts or behavior

One of the most concerning side effects of sertraline is an increased risk of suicidal thoughts or behavior. This is a rare but serious side effect that can occur in some individuals, especially in the first few weeks of treatment. If you experience any thoughts of suicide or self-harm while taking sertraline, it is important to seek immediate medical attention.

Serotonin syndrome

Serotonin syndrome is a rare but potentially life-threatening condition that can occur when there is too much serotonin in the body. It can be caused by taking sertraline in combination with other medications that increase serotonin levels or by taking too much sertraline. Symptoms of serotonin syndrome can include confusion, agitation, rapid heartbeat, high blood pressure, and fever. If you experience any of these symptoms while taking sertraline, it is important to seek immediate medical attention.

Bleeding or bruising

Sertraline can also increase the risk of bleeding or bruising. This is because sertraline can affect the way your blood clots. If you experience any unusual bleeding or bruising while taking sertraline, it is important to contact your doctor right away.

Seizures

Seizures are a rare but serious side effect of sertraline. If you have a history of seizures or epilepsy, you may be at a higher risk for experiencing seizures while taking sertraline. If you experience a seizure while taking sertraline, it is important to seek immediate medical attention.

Mania or hypomania

In some individuals, sertraline can cause episodes of mania or hypomania. These are periods of elevated or irritable mood, increased energy, and other symptoms that are characteristic of bipolar disorder. If you experience any symptoms of mania or hypomania while taking sertraline, it is important to contact your doctor right away.

In conclusion, while sertraline is generally considered safe and effective for the treatment of depression, anxiety disorders, OCD, PTSD, and PMDD, it can cause some rare but potentially serious side effects. These may include suicidal thoughts or behavior, serotonin syndrome, bleeding or bruising, seizures, and mania or hypomania. If you experience any of these side effects while taking sertraline, it is important to seek immediate medical attention. It is also important to talk to your doctor about any concerns you may have about taking sertraline, including the potential for side effects.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: