What are bad reactions to sertraline?

Sertraline is a medication that is commonly prescribed for the treatment of depression, anxiety disorders, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). While sertraline is generally considered safe and effective, it can cause some individuals to experience bad reactions or adverse reactions to the medication. Here are some examples of bad reactions to sertraline:

Allergic reaction

In rare cases, sertraline can cause an allergic reaction. Symptoms of an allergic reaction to sertraline may include hives, rash, itching, swelling, difficulty breathing, or chest pain. If you experience any of these symptoms, it is important to seek immediate medical attention.

Side effects

Sertraline can cause a variety of side effects, some of which may be bad reactions for certain individuals. Common side effects of sertraline can include nausea, diarrhea, headaches, and difficulty sleeping. Other side effects may include sexual dysfunction, changes in appetite or weight, and dry mouth. If you experience any severe or persistent side effects while taking sertraline, it is important to contact your doctor.

Serotonin syndrome

Serotonin syndrome is a rare but potentially life-threatening condition that can occur when there is too much serotonin in the body. Serotonin syndrome can be caused by taking sertraline in combination with other medications that increase serotonin levels or by taking too much sertraline. Symptoms of serotonin syndrome can include confusion, agitation, rapid heartbeat, high blood pressure, and fever. If you experience any of these symptoms while taking sertraline, it is important to seek immediate medical attention.

Withdrawal symptoms

If you stop taking sertraline abruptly, you may experience withdrawal symptoms. Withdrawal symptoms can include dizziness, nausea, headache, and irritability. To avoid withdrawal symptoms, it is important to talk to your doctor about gradually tapering off sertraline when it is time to stop taking the medication.

Drug interactions

Sertraline can interact with other medications, including over-the-counter medications and herbal supplements. Some drug interactions can cause bad reactions, such as increased risk of bleeding or serotonin syndrome. It is important to talk to your doctor about any medications or supplements you are taking before starting sertraline.

In conclusion, while sertraline is generally considered safe and effective for the treatment of depression, anxiety disorders, OCD, PTSD, and PMDD, it can cause bad reactions in some individuals. Bad reactions may include allergic reactions, side effects, serotonin syndrome, withdrawal symptoms, and drug interactions. If you experience any bad reactions to sertraline, it is important to seek immediate medical attention and talk to your doctor about alternative treatment options.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: