What organ does sertraline affect?

Sertraline is a medication that affects the central nervous system (CNS). It works by selectively inhibiting the reuptake of serotonin, a neurotransmitter in the brain that is involved in regulating mood, emotions, and behavior. By increasing the levels of serotonin in the brain, sertraline can help to alleviate symptoms of depression, anxiety disorders, OCD, PTSD, and PMDD.

Serotonin is produced in the brain and is involved in the regulation of mood, appetite, sleep, and other bodily functions. Sertraline works by blocking the reuptake of serotonin, which increases the availability of this neurotransmitter in the brain. This leads to increased activation of serotonin receptors and can help to improve mood and reduce symptoms of anxiety and depression.

While sertraline primarily affects the CNS, it can also have effects on other organs and systems in the body. For example, sertraline can affect the digestive system and may cause nausea, diarrhea, or constipation. It can also affect the cardiovascular system and may cause changes in heart rate or blood pressure. Additionally, sertraline can affect sexual function and may cause sexual side effects such as decreased libido or difficulty achieving orgasm.

Overall, sertraline primarily affects the central nervous system by increasing the availability of serotonin in the brain. However, it can also have effects on other organs and systems in the body, which is why it is important to talk to your doctor about any potential side effects or concerns you may have while taking this medication.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: