What to avoid when taking nortriptyline?

When taking nortriptyline, it is important to avoid certain medications, foods, and substances that may interact with the medication or increase the risk of side effects. Here are some things to avoid when taking nortriptyline:

  1. Alcohol: Drinking alcohol while taking nortriptyline can increase the risk of drowsiness, dizziness, and other side effects.
  2. Other medications: Nortriptyline can interact with other medications, including other antidepressants, antihistamines, and medications for high blood pressure or heart conditions. It is important to discuss any medications or supplements with a healthcare provider before taking nortriptyline.
  3. MAO inhibitors: Taking nortriptyline with a monoamine oxidase inhibitor (MAOI) can cause a serious and potentially life-threatening reaction. It is important to wait at least 14 days after stopping an MAOI before starting nortriptyline.
  4. Grapefruit juice: Drinking grapefruit juice while taking nortriptyline can increase the levels of the medication in the body, which may increase the risk of side effects.
  5. Smoking: Smoking can decrease the effectiveness of nortriptyline and increase the risk of side effects.

It is important to follow all instructions for taking nortriptyline and to avoid any medications, foods, or substances that may interact with the medication. If you have any questions or concerns about taking nortriptyline, it is important to discuss these with a healthcare provider, who can help determine the most appropriate treatment plan based on individual needs and medical history.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

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