Does agomelatine increase dopamine?

Agomelatine does not directly increase dopamine levels in the brain. Instead, it works by modulating the activity of the neurotransmitters melatonin and serotonin, which are involved in regulating mood and other physiological processes.

However, some studies have suggested that agomelatine may indirectly influence dopamine activity in the brain by increasing the sensitivity of dopamine receptors. This effect may contribute to the medication’s antidepressant effects, as dopamine is known to play a role in regulating mood and motivation.

It is important to note that the exact mechanism of action of agomelatine is not fully understood, and its effects on neurotransmitter activity in the brain may vary from person to person. The decision to use agomelatine or any other medication should be made in consultation with a healthcare provider, who can help determine the most appropriate treatment plan based on individual needs and medical history.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: