Is mirtazapine a strong sleeping pill?

Mirtazapine is a medication primarily used to treat depression and other mental health conditions. However, it has also been found to have sedative effects and is sometimes used as a sleeping aid. In this article, we’ll explore the use of mirtazapine as a sleeping pill, including its effectiveness, potential side effects, and other factors to consider.

How does mirtazapine work as a sleeping pill?

Mirtazapine works as a sleeping pill by blocking certain receptors in the brain that are involved in wakefulness and arousal. This can help to promote drowsiness and improve sleep quality. Additionally, mirtazapine can increase the levels of certain neurotransmitters, such as serotonin and norepinephrine, which can also promote relaxation and sleep.

Effectiveness of mirtazapine as a sleeping pill

Mirtazapine has been found to be effective in improving sleep quality and duration, particularly in patients with depression or anxiety. A study published in the Journal of Clinical Psychopharmacology found that mirtazapine improved sleep quality and decreased the time it took to fall asleep in patients with major depressive disorder.

However, it’s important to note that while mirtazapine can be effective as a sleeping pill, it is not considered a first-line treatment for insomnia. Other medications, such as benzodiazepines and non-benzodiazepine hypnotics, are typically used first. Additionally, mirtazapine is not recommended for long-term use as a sleeping pill due to the risk of dependence and other potential side effects.

Potential side effects of mirtazapine as a sleeping pill

Like any medication, mirtazapine can come with potential side effects. These can include:

  1. Drowsiness: While drowsiness is the desired effect when using mirtazapine as a sleeping pill, it can also cause excessive sleepiness or grogginess the following day.
  2. Dry mouth: Mirtazapine can cause dry mouth, which can be uncomfortable and increase the risk of dental problems.
  3. Increased appetite: Mirtazapine can increase appetite and cause weight gain in some patients.
  4. Dizziness: Mirtazapine can cause dizziness or lightheadedness, particularly when standing up quickly.

Other factors to consider

If you are considering using mirtazapine as a sleeping pill, it’s important to talk to your healthcare provider. They can provide guidance on the best treatment options for your individual needs and monitor your symptoms and side effects while taking the medication. Additionally, therapy and other non-medication treatments may be used in conjunction with mirtazapine to maximize the effectiveness of treatment.

It’s also important to note that mirtazapine can interact with other medications and supplements, and may not be safe for everyone to take. Your healthcare provider can help determine if mirtazapine is a safe and appropriate treatment option for you.


Mirtazapine is a medication commonly used to treat depression and other mental health conditions. While it can be effective as a sleeping pill, it is not considered a first-line treatment for insomnia and should only be used under the guidance of a healthcare provider. By understanding the strengths and limitations of mirtazapine as a sleeping pill, you can make informed decisions about your sleep and overall well-being.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: