Understanding Valdoxan: An In-depth Look at Its Uses, Side Effects, and More

Valdoxan, also known by its generic name agomelatine, is a prescription medication primarily used to treat major depressive episodes in adults. This unique antidepressant has a different mechanism of action than traditional antidepressants, offering some unique benefits but also carrying its own set of potential side effects. This comprehensive guide will delve into what you need to know about Valdoxan, including its potential side effects and the much-discussed topic of weight gain associated with its use.

What is Valdoxan?

Before we dive into the side effects, let’s understand what Valdoxan is and how it works. Valdoxan is an atypical antidepressant that works by modulating the body’s melatonin receptors. It helps reset the body’s circadian rhythm, which is often disrupted in people with depression. This unique mechanism of action distinguishes it from other classes of antidepressants, and it’s thought to contribute to its unique side effect profile.

The Side Effects of Valdoxan

Like all medications, Valdoxan has potential side effects. These can range from mild and tolerable to more severe. It’s important to remember that not everyone will experience these side effects, and many people tolerate Valdoxan quite well.

Common Side Effects

The most common side effects of Valdoxan are usually mild and tend to decrease over time as your body adjusts to the medication. These may include:

Most of these side effects are transient and will resolve on their own. However, if they persist or become bothersome, it’s important to discuss them with your healthcare provider.

Less Common and Serious Side Effects

Less common but more serious side effects can also occur with Valdoxan. These include:

  • Changes in liver function: Valdoxan can affect liver function, so regular liver function tests are usually recommended for those taking this medication.
  • Skin reactions: In rare cases, individuals may experience serious skin reactions such as erythema multiforme, a type of allergic reaction causing red, often itchy or painful patches on the skin.
  • Increased suicidal thoughts: As with many antidepressants, Valdoxan can increase suicidal thoughts, particularly in individuals under 25.

If you experience any of these side effects or notice any other changes that concern you, seek medical attention immediately.

Valdoxan and Weight Gain

An essential aspect of understanding Valdoxan’s side effects involves addressing the topic of weight gain. Weight gain is a common concern among individuals prescribed antidepressants, and rightly so, as many antidepressants can indeed lead to weight changes.

But what about Valdoxan? Does it cause weight gain? The answer is a bit nuanced.

In clinical trials, weight gain has not been reported as a common side effect of Valdoxan. In fact, compared to other antidepressants, Valdoxan is often touted for its neutral effect on weight. However, everyone responds to medications differently, and some people might experience changes in weight while taking Valdoxan.

Remember that weight changes can be influenced by numerous factors, including diet, physical activity levels, other medications, and the underlying condition being treated (in this case, depression). If you’re concerned about weight changes while taking Valdoxan, it’s crucial to discuss this with your healthcare provider.

Key Takeaways

Valdoxan offers a unique approach to treating depression, affecting the body’s melatonin receptors to help reset the circadian rhythm—along with its potential benefits come potential side effects. While many people tolerate Valdoxan well, it’s essential to be aware of the possible side effects, including the less common but more serious ones.

Weight gain, a common concern with many antidepressants, is not typically associated with Valdoxan use. However, individual experiences can vary, and it’s important to monitor any changes and discuss them with your healthcare provider.

The goal of any treatment plan is to find a balance between managing symptoms effectively while minimizing potential side effects. Always consult with your healthcare provider if you have any concerns or questions about your medication. Remember, you are the most important member of your healthcare team, and your input is invaluable in tailoring a treatment approach that works best for you.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: