Who should not take bupropion?

Quick answer: Bupropion should not be taken by people with a history of seizures, eating disorders (like bulimia or anorexia), or those using MAO inhibitors. It should also be used cautiously in individuals with bipolar disorder or known allergies to bupropion.

Bupropion is an antidepressant medication that can be effective for treating depression, smoking cessation, and other conditions. However, there are certain individuals who should not take bupropion or who should use caution when taking the medication. Here are some groups of people who should not take bupropion:

  1. Individuals with a history of seizures:
    Bupropion may lower the seizure threshold and increase the risk of seizures, particularly in individuals who have a history of seizures or other conditions that may increase the risk of seizures. Therefore, bupropion is contraindicated in individuals with a seizure disorder or a history of seizures.
  2. Individuals with an eating disorder:
    Bupropion may increase the risk of seizures, particularly in individuals with an eating disorder such as bulimia or anorexia nervosa. Therefore, bupropion is contraindicated in individuals with a current or prior diagnosis of an eating disorder.
  3. Individuals who are allergic to bupropion or any of its components:
    Bupropion may cause an allergic reaction in some individuals, particularly those who are allergic to bupropion or any of its components. Therefore, bupropion should not be taken by individuals who are allergic to the medication.
  4. Individuals taking certain medications:
    Bupropion may interact with certain medications, such as monoamine oxidase inhibitors (MAOIs), and may increase the risk of serious side effects such as seizures, high blood pressure, and serotonin syndrome. Therefore, bupropion should not be taken by individuals taking MAOIs or other medications that interact with bupropion.
  5. Individuals with a history of bipolar disorder:
    Bupropion may increase the risk of mania or hypomania, particularly in individuals with a history of bipolar disorder. Therefore, bupropion should be used with caution in individuals with a history of bipolar disorder or other mood disorders.

It is important to only take bupropion as prescribed by a healthcare provider and to follow their instructions carefully. If you have any questions or concerns about your medication regimen, it is important to discuss these with your healthcare provider.

Related Questions (FAQ)

How Does Bupropion XL Make You Feel?

Bupropion XL often helps people feel more motivated, energetic, and emotionally balanced without the emotional numbness seen with some SSRIs. During the first weeks, mild anxiety, insomnia, or restlessness may appear before mood and focus noticeably improve. Most users report feeling “lighter” and more alert once their body adjusts.

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Wellbutrin SR vs XL: Which Is Better for You?

Bottom line: SR and XL work about the same for depression; XL’s once-daily, smoother release often fits busy routines and may reduce peak-related side effects (jitters, nausea, headache).

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Is 300 mg of Bupropion XL Considered a High Dose?

A 300 mg daily dose of Bupropion XL is generally considered a standard therapeutic amount — not unusually high, but on the upper end of the typical range (150 mg – 450 mg/day). For most patients, it balances strong antidepressant effects with manageable side-effect risk, though it should always be monitored by a doctor.

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Why take Lexapro and Wellbutrin together?

Doctors may prescribe Lexapro (escitalopram) and Wellbutrin (bupropion) together to treat depression or anxiety more effectively. Lexapro increases serotonin levels, improving mood and calmness, while Wellbutrin boosts dopamine and norepinephrine, enhancing energy and motivation. The combination can balance emotional stability and focus while reducing sexual side effects or fatigue from SSRI therapy.

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Can you take Wellbutrin and an Antipsychotic?

Yes, Wellbutrin (bupropion) can sometimes be taken with an antipsychotic under close medical supervision. This combination may help manage both depressive and psychotic symptoms by balancing dopamine, norepinephrine, and serotonin activity. However, it increases the risk of seizures and interactions, so dosage and monitoring must be tailored by a psychiatrist.

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Is Vraylar better than Wellbutrin?

Vraylar (cariprazine) and Wellbutrin (bupropion) serve different roles—Vraylar treats bipolar disorder and schizophrenia, while Wellbutrin addresses depression and low motivation. One isn’t “better” than the other; the right choice depends on the condition being treated, side-effect tolerance, and individual response under a doctor’s supervision.

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Disclaimer: Educational content only. Always follow your doctor/pharmacist. Official patient leaflets & emergency contacts: Drug Safety Resources.