Who should not take mirtazapine?

Mirtazapine may not be suitable for everyone, and there are certain individuals who should not take this medication. Some examples include:

  1. Allergy to mirtazapine: People who are allergic to mirtazapine or any of its ingredients should not take this medication.
  2. Use of MAO inhibitors: Mirtazapine should not be taken by individuals who are currently taking or have recently taken a monoamine oxidase inhibitor (MAOI) medication, as this combination can cause serious and potentially life-threatening side effects.
  3. Liver disease: Mirtazapine is broken down by the liver, so individuals with severe liver disease may not be able to process the medication properly.
  4. Pregnancy and breastfeeding: The safety of mirtazapine during pregnancy and breastfeeding has not been thoroughly studied, and it may not be safe for these populations.
  5. Children: Mirtazapine is not approved for use in children under the age of 18.

It is important to discuss any medical conditions, allergies, or medications you are taking with your healthcare provider before starting mirtazapine or any other medication. Your healthcare provider can help determine whether mirtazapine is a safe and appropriate treatment option for you.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

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