Quick answer: Bupropion itself doesn’t cause bipolar disorder, but it can trigger manic or hypomanic episodes in people who already have—or are predisposed to—bipolar disorder. Close monitoring is essential if you or your family have a history of bipolar symptoms.
There is some evidence to suggest that bupropion may increase the risk of manic or hypomanic episodes in individuals who have a history of bipolar disorder or who are at risk for bipolar disorder.
Bupropion is classified as an atypical antidepressant or dopamine and norepinephrine reuptake inhibitor (DNRI), as it works by blocking the reuptake of dopamine and norepinephrine in the brain. These neurotransmitters are involved in regulating mood, motivation, and other brain functions.
While bupropion can be effective in treating depression and other conditions, it may also increase the risk of manic or hypomanic episodes in some individuals. This risk appears to be higher in individuals with a prior history of bipolar disorder, as well as those with a family history of bipolar disorder.
If you have a history of bipolar disorder or other mood disorders, it is important to discuss the risks and benefits of bupropion with your healthcare provider before starting the medication. They may recommend other treatment options or closely monitor you for signs of mood changes while taking bupropion.
If you experience any changes in mood or other symptoms while taking bupropion, it is important to report these to your healthcare provider. They can help determine the underlying cause and recommend appropriate treatment options.
Related Questions (FAQ)
How Does Bupropion XL Make You Feel?
Bupropion XL often helps people feel more motivated, energetic, and emotionally balanced without the emotional numbness seen with some SSRIs. During the first weeks, mild anxiety, insomnia, or restlessness may appear before mood and focus noticeably improve. Most users report feeling “lighter” and more alert once their body adjusts.
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Wellbutrin SR vs XL: Which Is Better for You?
Bottom line: SR and XL work about the same for depression; XL’s once-daily, smoother release often fits busy routines and may reduce peak-related side effects (jitters, nausea, headache).
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Is 300 mg of Bupropion XL Considered a High Dose?
A 300 mg daily dose of Bupropion XL is generally considered a standard therapeutic amount — not unusually high, but on the upper end of the typical range (150 mg – 450 mg/day). For most patients, it balances strong antidepressant effects with manageable side-effect risk, though it should always be monitored by a doctor.
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Why take Lexapro and Wellbutrin together?
Doctors may prescribe Lexapro (escitalopram) and Wellbutrin (bupropion) together to treat depression or anxiety more effectively. Lexapro increases serotonin levels, improving mood and calmness, while Wellbutrin boosts dopamine and norepinephrine, enhancing energy and motivation. The combination can balance emotional stability and focus while reducing sexual side effects or fatigue from SSRI therapy.
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Can you take Wellbutrin and an Antipsychotic?
Yes, Wellbutrin (bupropion) can sometimes be taken with an antipsychotic under close medical supervision. This combination may help manage both depressive and psychotic symptoms by balancing dopamine, norepinephrine, and serotonin activity. However, it increases the risk of seizures and interactions, so dosage and monitoring must be tailored by a psychiatrist.
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Is Vraylar better than Wellbutrin?
Vraylar (cariprazine) and Wellbutrin (bupropion) serve different roles—Vraylar treats bipolar disorder and schizophrenia, while Wellbutrin addresses depression and low motivation. One isn’t “better” than the other; the right choice depends on the condition being treated, side-effect tolerance, and individual response under a doctor’s supervision.
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