The 10 Most Common Side Effects of Venlafaxine – 6 Tips to Manage and Minimize Them

If you are taking venlafaxine, a medication that is used to treat depression, anxiety, and other mood disorders, you may experience side effects. While not everyone experiences them, side effects are a common and often predictable part of taking medications. Understanding the most common side effects of venlafaxine can help you prepare for them, manage them, and minimize their impact on your daily life. In this article, we will explore the most common venlafaxine side effects, their causes, and some tips to cope with them.

What is Venlafaxine and How Does it Work?

Venlafaxine is a medication that belongs to the class of serotonin-norepinephrine reuptake inhibitors (SNRIs). It works by increasing the levels of serotonin and norepinephrine, two neurotransmitters that regulate mood, emotions, and pain, in the brain. By blocking the reuptake of these neurotransmitters, venlafaxine enhances their effects and improves the symptoms of depression and anxiety. Venlafaxine is available in various forms, including immediate-release tablets, extended-release capsules, and oral solutions.

What are the Most Common Side Effects of Venlafaxine?

The most common side effects of venlafaxine include:

  1. Nausea and vomiting: About 20-30% of people taking venlafaxine experience nausea, which can range from mild to severe. Some people may also vomit or feel queasy.
  2. Headache: About 20-30% of people taking venlafaxine experience headaches, which can range from mild to severe. The headaches may be related to changes in blood pressure or serotonin levels.
  3. Dizziness: About 20-30% of people taking venlafaxine experience dizziness, which can range from mild to severe. Dizziness may be related to changes in blood pressure, dehydration, or inner ear problems.
  4. Insomnia or sleepiness: About 20-30% of people taking venlafaxine experience changes in their sleep patterns, such as insomnia (difficulty falling or staying asleep) or sleepiness (feeling tired or drowsy).
  5. Sweating: About 10-20% of people taking venlafaxine experience excessive sweating, which can be uncomfortable and embarrassing. Sweating may be related to changes in the autonomic nervous system.
  6. Dry mouth: About 10-20% of people taking venlafaxine experience dry mouth, which can make it difficult to speak, eat, or drink. Dry mouth may be related to changes in salivary gland function.
  7. Constipation: About 10-20% of people taking venlafaxine experience constipation, which can be uncomfortable and may require dietary or medication changes. Constipation may be related to changes in gastrointestinal motility.
  8. Sexual dysfunction: About 10-20% of people taking venlafaxine experience sexual dysfunction, such as decreased libido, erectile dysfunction, or delayed orgasm. Sexual dysfunction may be related to changes in serotonin and norepinephrine levels.
  9. Anxiety or agitation: About 10-20% of people taking venlafaxine experience increased anxiety or agitation, which can be distressing and may require changes in medication or dosage. Anxiety or agitation may be related to changes in neurotransmitter balance or brain chemistry.
  10. Weight changes: About 5-10% of people taking venlafaxine experience weight changes, such as weight loss or weight gain, which can affect body image and self-esteem. Weight changes may be related to changes in appetite, metabolism, or fluid balance.

What Causes the Side Effects of Venlafaxine?

The side effects of venlafaxine are caused by its effects on the brain and body. By increasing the levels of serotonin and norepinephrine, venlafaxine can affect various organs and systems, including the digestive, cardiovascular, nervous, and endocrine systems. The side effects of venlafaxine may also be influenced by individual factors, such as age, gender, health status, genetics, and lifestyle. For example, older adults may be more susceptible to dizziness or falls, while people with liver or kidney problems may experience more severe side effects. Additionally, the dosage, timing, and duration of venlafaxine may also affect the side effects. Higher doses or longer use may increase the risk and severity of side effects.

Infographic for Most Common Side Effects of Venlafaxine – Tips to Manage and Minimize Them
Infographic about managing and minimizing the most common side fffects of Venlafaxine

How to Manage and Minimize the Side Effects of Venlafaxine?

While the side effects of venlafaxine can be challenging, there are some strategies that can help you manage and minimize them. Here are some tips:

  1. Talk to your healthcare provider: Your healthcare provider can help you understand the side effects of venlafaxine, monitor your symptoms, and adjust your dosage or medication as needed. They can also suggest other treatments or lifestyle changes that may help alleviate the side effects, such as anti-nausea medications, headache remedies, or exercise programs. It’s important to follow your healthcare provider’s instructions and not to stop or change your medication without their guidance, as abrupt or improper withdrawal can lead to serious symptoms, such as seizures or suicidal thoughts.
  2. Take your medication as directed: To minimize the side effects of venlafaxine, it’s important to take your medication as directed, usually once or twice a day, with food or water. Avoid crushing, chewing, or breaking the extended-release capsules, as this can release the medication too quickly and increase the risk of side effects. If you miss a dose, take it as soon as you remember, unless it’s close to the next dose, in which case you should skip the missed dose and resume your regular schedule.
  3. Stay hydrated and nourished: To prevent or alleviate nausea, dry mouth, constipation, or sweating, it’s important to stay hydrated and nourished. Drink plenty of water, herbal tea, or clear liquids to flush out toxins and replenish fluids. Eat a balanced diet of whole grains, fruits, vegetables, lean protein, and healthy fats to provide energy and nutrients. Avoid alcohol, caffeine, or spicy foods, as they can irritate your stomach or dehydrate you.
  4. Practice good sleep hygiene: To address sleep-related side effects, such as insomnia or sleepiness, it’s important to practice good sleep hygiene. This includes establishing a regular sleep schedule, avoiding screens and stimulating activities before bedtime, creating a comfortable and quiet sleep environment, and using relaxation techniques, such as deep breathing, meditation, or yoga. If you still have trouble sleeping, talk to your healthcare provider about sleep aids or other options.
  5. Exercise regularly and safely: To improve your mood, energy, and overall health, it’s important to exercise regularly and safely. This can also help alleviate side effects, such as weight changes, anxiety, or sexual dysfunction. Aim for at least 30 minutes of moderate-intensity exercise, such as brisk walking, cycling, or swimming, most days of the week. Start slowly and gradually increase your intensity and duration. Wear comfortable and supportive shoes, clothing, and gear. Consult your healthcare provider before starting a new exercise program, especially if you have any health concerns or limitations.
  6. Seek support and self-care: To cope with the emotional and social impact of side effects, it’s important to seek support and practice self-care. This can include talking to a therapist, joining a support group, connecting with friends and family, engaging in hobbies or creative activities, or practicing mindfulness or self-compassion. Remember that you are not alone and that side effects are a normal and temporary part of taking medication. Be kind and patient with yourself, and seek help if you need it.

Conclusion

Taking venlafaxine can help improve your mood and quality of life, but it can also cause side effects. Understanding the most common side effects of venlafaxine, their causes, and some tips to cope with them can help you prepare for them, manage them, and minimize their impact on your daily life. Remember to talk to your healthcare provider, take your medication as directed, stay hydrated and nourished, practice good sleep hygiene, exercise regularly and safely, and seek support and self-care. By working together, you can find the right balance of benefits and risks and achieve your treatment goals.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: