Does bupropion increase dopamine or serotonin?

Bupropion primarily increases the levels of dopamine and norepinephrine in the brain, although it may also have some effects on serotonin levels.

Bupropion is classified as an atypical antidepressant or dopamine and norepinephrine reuptake inhibitor (DNRI). It works by blocking the reuptake of dopamine and norepinephrine in the brain, which increases their availability and can improve symptoms of depression and anxiety.

While bupropion does not directly affect serotonin levels, it may have some indirect effects on serotonin function. For example, bupropion’s effects on dopamine and norepinephrine may influence serotonin function and contribute to its effectiveness in treating conditions such as depression and anxiety.

Overall, bupropion’s effects on neurotransmitters in the brain can help regulate mood, energy, motivation, and other brain functions. It is important to only take bupropion as prescribed by a healthcare provider and to follow their instructions carefully.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

Does bupropion make you hungry?

Does bupropion increase GABA?