How safe is sertraline?

Sertraline is generally considered to be a safe medication when used as prescribed and under the guidance of a healthcare professional. However, like all medications, sertraline does carry some risks, and it is important to be aware of these risks before starting the medication.

Some potential side effects of sertraline include:

  1. Gastrointestinal symptoms, such as nausea, diarrhea, and constipation
  2. Headache
  3. Insomnia or drowsiness
  4. Sexual dysfunction
  5. Weight gain

Sertraline can also interact with other medications and supplements, so it is important to talk to your doctor about any other medications or supplements you are taking before starting sertraline.

In rare cases, sertraline may cause more serious side effects, such as:

  1. Suicidal thoughts or behaviors, particularly in children, adolescents, and young adults
  2. Serotonin syndrome, a potentially life-threatening condition that can occur when there is too much serotonin in the brain
  3. Seizures
  4. Hyponatremia, a condition in which there is a low level of sodium in the blood

It is important to monitor for these more serious side effects and seek medical attention immediately if they occur.

Overall, sertraline is considered to be a safe and effective medication for treating depression, anxiety, and other mood disorders. However, it is important to be aware of the potential side effects and risks associated with the medication, and to work closely with your doctor to determine the best treatment plan for your unique needs.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

Can I stop sertraline after 2 days?

How quickly does sertraline work?