Olanzapine vs Amisulpride: Which Medication is Right for You?

When it comes to treating schizophrenia and related disorders, there are many medications to choose from. Olanzapine and Amisulpride are two medications that are commonly prescribed, but which one is right for you? In this blog post, we’ll compare Olanzapine and Amisulpride and provide you with the information you need to make an informed decision.

Overview of Olanzapine and Amisulpride

Olanzapine and Amisulpride are both antipsychotic medications that are used to treat schizophrenia and related disorders. Olanzapine works by blocking the receptors in the brain that respond to dopamine, while Amisulpride works by blocking the receptors that respond to dopamine and serotonin. Both medications are available in tablet form and require a prescription from a healthcare provider.

Efficacy and Effectiveness

Studies have shown that both Olanzapine and Amisulpride can be effective in treating schizophrenia and related disorders. However, Olanzapine has been found to be more effective in reducing positive symptoms, such as hallucinations and delusions, while Amisulpride has been found to be more effective in reducing negative symptoms, such as apathy and lack of motivation. In addition, Olanzapine has been found to be effective in treating bipolar disorder, while Amisulpride has not been studied as extensively for this use.

Side Effects

Both Olanzapine and Amisulpride can cause side effects, some of which can be serious. The most common side effects associated with Olanzapine include weight gain, increased appetite, drowsiness, and dry mouth. The most common side effects associated with Amisulpride include insomnia, anxiety, agitation, and akathisia (restlessness). Both medications can also cause more serious side effects, such as tardive dyskinesia, which is a movement disorder that can be irreversible.

Dosage and Administration

The recommended starting dose for Olanzapine is 5-10 mg per day, while the recommended starting dose for Amisulpride is 400-800 mg per day. Both medications are usually taken once per day, although Olanzapine can be taken in divided doses if necessary. It’s important to follow your healthcare provider’s instructions regarding dosage and administration.


The cost of Olanzapine and Amisulpride can vary depending on your location and insurance coverage. On average, Olanzapine is more expensive than Amisulpride. However, both medications may be covered by insurance, so it’s important to check with your provider.

Olanzapine vs Amisulpride Pros and Cons

OlanzapineEffective in reducing positive symptomsMore likely to cause weight gain and metabolic issues
Can be effective in treating bipolar disorderMore expensive than Amisulpride
Available in various forms, including orally disintegrating tabletsCan cause significant sedation
AmisulprideEffective in reducing negative symptomsMore likely to cause akathisia and other movement disorders
May have a lower risk of metabolic issuesMay not be as effective in treating positive symptoms
Less expensive than OlanzapineNot as widely available as Olanzapine

It’s important to note that the pros and cons listed in this table are not exhaustive and may vary from person to person. It’s always best to consult with a healthcare provider before making any decisions regarding medication.


Both Olanzapine and Amisulpride are effective medications for treating schizophrenia and related disorders, but they have different pros and cons. It’s important to work with your healthcare provider to determine which medication is best for you based on your specific needs and circumstances. While Olanzapine may be more effective in reducing positive symptoms, Amisulpride may be more effective in reducing negative symptoms. It’s also important to consider the potential side effects of each medication and the cost. With the right medication and support, it’s possible to manage schizophrenia and related disorders and live a fulfilling life.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: