What are the scary side effects of sertraline?

While sertraline is generally considered safe and effective for the treatment of depression, anxiety disorders, OCD, PTSD, and PMDD, it can cause side effects in some individuals. Most side effects of sertraline are mild and go away on their own after a few days or weeks. However, there are some rare but potentially serious side effects that can occur. Here are some of the scary side effects of sertraline:

Suicidal thoughts or behavior

One of the most concerning side effects of sertraline is an increased risk of suicidal thoughts or behavior. This is a rare but serious side effect that can occur in some individuals, especially in the first few weeks of treatment. If you experience any thoughts of suicide or self-harm while taking sertraline, it is important to seek immediate medical attention.

Serotonin syndrome

Serotonin syndrome is a rare but potentially life-threatening condition that can occur when there is too much serotonin in the body. It can be caused by taking sertraline in combination with other medications that increase serotonin levels or by taking too much sertraline. Symptoms of serotonin syndrome can include confusion, agitation, rapid heartbeat, high blood pressure, and fever. If you experience any of these symptoms while taking sertraline, it is important to seek immediate medical attention.

Bleeding or bruising

Sertraline can also increase the risk of bleeding or bruising. This is because sertraline can affect the way your blood clots. If you experience any unusual bleeding or bruising while taking sertraline, it is important to contact your doctor right away.

Seizures

Seizures are a rare but serious side effect of sertraline. If you have a history of seizures or epilepsy, you may be at a higher risk for experiencing seizures while taking sertraline. If you experience a seizure while taking sertraline, it is important to seek immediate medical attention.

Mania or hypomania

In some individuals, sertraline can cause episodes of mania or hypomania. These are periods of elevated or irritable mood, increased energy, and other symptoms that are characteristic of bipolar disorder. If you experience any symptoms of mania or hypomania while taking sertraline, it is important to contact your doctor right away.

In conclusion, while sertraline is generally considered safe and effective for the treatment of depression, anxiety disorders, OCD, PTSD, and PMDD, it can cause some rare but potentially serious side effects. These may include suicidal thoughts or behavior, serotonin syndrome, bleeding or bruising, seizures, and mania or hypomania. If you experience any of these side effects while taking sertraline, it is important to seek immediate medical attention. It is also important to talk to your doctor about any concerns you may have about taking sertraline, including the potential for side effects.

Related Questions (FAQ)

How Does Bupropion XL Make You Feel?

Bupropion XL often helps people feel more motivated, energetic, and emotionally balanced without the emotional numbness seen with some SSRIs. During the first weeks, mild anxiety, insomnia, or restlessness may appear before mood and focus noticeably improve. Most users report feeling “lighter” and more alert once their body adjusts.

Read full answer →

Wellbutrin SR vs XL: Which Is Better for You?

Bottom line: SR and XL work about the same for depression; XL’s once-daily, smoother release often fits busy routines and may reduce peak-related side effects (jitters, nausea, headache).

Read full answer →

Is 300 mg of Bupropion XL Considered a High Dose?

A 300 mg daily dose of Bupropion XL is generally considered a standard therapeutic amount — not unusually high, but on the upper end of the typical range (150 mg – 450 mg/day). For most patients, it balances strong antidepressant effects with manageable side-effect risk, though it should always be monitored by a doctor.

Read full answer →

Why take Lexapro and Wellbutrin together?

Doctors may prescribe Lexapro (escitalopram) and Wellbutrin (bupropion) together to treat depression or anxiety more effectively. Lexapro increases serotonin levels, improving mood and calmness, while Wellbutrin boosts dopamine and norepinephrine, enhancing energy and motivation. The combination can balance emotional stability and focus while reducing sexual side effects or fatigue from SSRI therapy.

Read full answer →

Can you take Wellbutrin and an Antipsychotic?

Yes, Wellbutrin (bupropion) can sometimes be taken with an antipsychotic under close medical supervision. This combination may help manage both depressive and psychotic symptoms by balancing dopamine, norepinephrine, and serotonin activity. However, it increases the risk of seizures and interactions, so dosage and monitoring must be tailored by a psychiatrist.

Read full answer →

Is Vraylar better than Wellbutrin?

Vraylar (cariprazine) and Wellbutrin (bupropion) serve different roles—Vraylar treats bipolar disorder and schizophrenia, while Wellbutrin addresses depression and low motivation. One isn’t “better” than the other; the right choice depends on the condition being treated, side-effect tolerance, and individual response under a doctor’s supervision.

Read full answer →

Disclaimer: Educational content only. Always follow your doctor/pharmacist. Official patient leaflets & emergency contacts: Drug Safety Resources.